Yes true, Motilium is domperidone, an anti-emetic (prevents emesis or vomiting and reduces nausea), it acts my increasing the peristaltic movement of the intestines and enhancing the stomach's contractions, and Nexium is esomeprazole, a proton pump inhibitor,it acts by blocking acid producing channels in the stomach to reduce the acidity of the medium in the stomach. If indeed gastroesophageal reflux disease (GERD) exists, we expect that there would be recurrent and frequent return of not only the stomach contents of food, but also of the stomachal acid, from the stomach up to the esophagus and reaching the larynx (throat) where the vocal cords are located. This acid flux occurs because the ring of muscles that connects the end of the esophagus to the entrance of the stomach, and which is supposed to contract to prevent the return backward of stomach content, is loose. Now this acid causes repetitive irritation to the larynx, the response to which would be an irritative cough. This is why when we suspect that a child has GERD as the underlying cause of their chronic cough (and not a problem in the lungs or sinuses for example), we prescribe anti-reflux therapy. Other doctors prefer to initially document that there is GERD with a special kind of imaging, others skip this step and give a trial of therapy - if the child improves then this would be a confirmation that they have GERD.
I hope my answer was detailed enough to address your concerns.
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