Klavox is made up of two main components: Amoxicillin, the antibiotic, and Clavulanic acid, which enhances the anti microbial activity of amoxicillin. Clavulanic acid is widely used for antimicrobial therapy in association with this class of antibiotics. Despite this, very few adverse reactions to the molecule have been so far reported in the medical literature. Recently, however, a case of not-immediate reaction to clavulanic acid has been described in a young adult who previously tolerated it. The patient complained of generalized itchy skin redness two days after completing a course of amoxicillin-clavulanate therapy, and had no previous clinical history of adverse reactions to drugs. This is an IgE-mediated hypersensitivity reaction to clavulanic acid, a rare incident, since this molecule is poorly allergenic. IgE is an antibody that is released in allergic reactions by a certain type of white blood cells, the T cells.
The particular type of reaction you had is known as Exfoliative dermatitis, a widespread redness and scaling of the skin. Signs and symptoms include pruritus (itchiness) , malaise, and chills. Diffuse erythema (redness) initially occurs in patches but spreads and affects all or nearly all of the body. Extensive epidermal sloughing (where the skin looks and feels like it's burbed) occurs.
Diagnosis is by history and examination.
Treatment is based on:
- Supportive care (eg, rehydration)
-Topical care (eg, emollients, colloidal oatmeal baths)
- Corticosteroids: usually topical creams for limited disease, and systemic for severe disease.
Prognosis depends on the cause. Cases related to drug reactions have the shortest duration, lasting 2 to 6 wk after the drug is withdrawn.
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It is recommended that all individuals see a Family Doctor for a full medical examination annually. Adults should get their blood pressure checked (US Preventive Task Force), a flu vaccine (CDC) and more each year.
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It’s recommended by the American Academy of Ophthalmology that every adult between the ages of 18 and 80 does an eye examination at least once every two years.
It's recommended by the American Cancer Association that every adult between the age of 20 and 80 does an annual skin screening by a licensed dermatologist.
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