Leaving socks on all the time would increase the risk of fungal infection. However in winter, when it's cold weather and the humidity is less there is lower risk of such infections and they can be left while sleeping. But in this case they should be changed frequently.
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It is recommended that all individuals see a Family Doctor for a full medical examination annually. Adults should get their blood pressure checked (US Preventive Task Force), a flu vaccine (CDC) and more each year.