Depression is due to a hormonal imbalance in your brain. The most important hormone is serotonin. When it decreases, you can suffer from depression. 50% of the time, there is no reason for the serotonin to decrease and it just drops suddenly. In the other 50%, stressors and causes may be responsible.
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It is recommended that all individuals see a Family Doctor for a full medical examination annually. Adults should get their blood pressure checked (US Preventive Task Force), a flu vaccine (CDC) and more each year.