I made DNA analysis, the result were: Factore XIII is homozygous( mutant) Hetrozygous for: FII, PAI-1, HPA1,MTHFR(C667T),MTHFR(A1298C) D/D for ACE type E3/E3 forvApo E. What are the maining of this
for what cause has the test been done ?are you pregnant or having problem with fertility or miscarriage ,have any other bleeding or blood clotting problems ,the results alone will not been interpreted that much without the symptoms and purpose that the test been held .
These blood studies are done in case there are known risk factors in your family for bleeding or exaggerated blood clotting, to know if you too have such risk factors which play a role in cardiovascular disease and pregnancy (recurrent unexplained pregnancy loss can have as underlying cause a state of thrombophilia in thebblood, ie blood that forms a lot of clots).
Normally, there is a fine balance in the body which ensures that there is not too much bleeding or blood clotting. If this balance is disrupted, a blood clot may occur. In response to injury, the body naturally triggers the “clotting cascade”—a sequence of events that allows the blood cells (platelets) and clotting proteins to respond to the site of the injury to clog up the vessel and stop bleeding, and then to repair it. in a person with thrombophilia, blood clotting proteins exist in abnormal amounts, so that the clotting overshoots and a big blood clot may form.
Homozygous for factor XIII, one of the proteins in the clotting cascade, signifies a tendency to bleed (not clot). Heterozygous for Factor II (another clotting cascade protein)
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